Table 1.

EBV-miRNAs and its targets in NPC

EBV-miRNAs	Targets	Function of targets	Ref
miR-BART 2-5P	MICB	Ligand of NKG2D receptor	24
miR-BART 11-5p	EBF1	B cell proliferation and differenciation	29
miR-BART 3	IPO7	Immunoregulatory factor	31
miR-BART 22 miR-BART 6-3p	LMP2A RIG-I	Initiation of latent cycle pattern recognition receptors	21 22
miR-BART 9	LMP1	Immortalization of B cells	51
miR-BART 5-5p,16	LMP1	Immortalization of B cells	52
3-3p, 17-5p,20			98
miR-BART 6-5p	Dicer,Zta,Rta	Catalytic miRNA mature	56
	EBNA2	Lytic replication	56
miR-BART 2	BALF5	DNA polymerase	19
miR-BHRF 1	P53	Late lytic replication	57
miR-BART 18-5p BART5-5p,7-3p, 9-3p,14-3p	MAP3K2 ATM	Protein phosphorylation DNA double-strand break repair gene	63 64
miR-BART 11	FOXP1	Cell differentiation	65
miR-BART 19-3p	WIF1	Wnt inhibitory genes	66
miR-BART 19-3p,7,17-5p	APC	Wnt inhibitory genes	66
miR-BART19-3p,14,18-5p	NLK	STAT inhibitory genes	99
miR-BART 3*	DICE1	Tumor suppressor	70
miR-BART 7	C-Myc,C-Jun	Transcription factor	71, 73
miR-BART 1	G6PD,SAT1	Metabolism-associated enzymes	74
miR-BART 5	PUMA	Pro-apoptotic protein	79
miR-BART I,II cluster	Bim	Pro-apoptotic protein	80
miR-BART 16	TOM22	Bax mitochondrial receptor	31, 82
miR-BART 1-5p,16,17-5p	LMP1	Immortalization of B cells	83
miR-BART I cluster	LMP1	Immortalization of B cells	52
miR-BART3#	FEM1B,CASZ1a	Pro-apoptotic protein	78
miR-BART6#	OCT1	Pro-apoptotic protein	78
miR-BART8#	ARID2	Pro-apoptotic protein	78
miR-BART16#	CREBBP,SH2B3	Pro-apoptotic protein	78
EBV-miRNAs	Targets	Function of targets	Ref
miR-BART22#	PPP3R1,TP53INP1,PAK2	Pro-apoptotic protein	78
miR-BART 7-3p,1	PTEN	Tumor suppressor	72, 83
miR-BART 9,18-5p	PTEN	Tumor suppressor	66, 89
miR-BART 10-3p	BTRC	Ubiquitin of β-catenin and snail	90
miR-BART 22 miR-BART 6-3p miR-BART 9	MAP3K5 LOC553103 E-cadherin	P38MAPK early response genes Suppress EMT Mediate cell aggregation	91 92 93

# Identified EBV BART miRNA-mRNA targets, but its anti-apoptotic effect remains to be proven.

Ref: reference