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. 2018 Jul 16;9(16):2834–2843. doi: 10.7150/jca.26046

Figure 1.

Figure 1

LINC00460 expression is upregulated in human colorectal cancer and associated with poor prognosis. A. RNA-Seq data from TCGA for LINC00460 in COAD were revealed using CRN (http://syslab4.nchu.edu.tw/). B. LINC00460 expression in COAD tissues (n=275) compared with that in non-cancerous tissues (n=349) was analyzed by using the GEPIA database. C. ISH revealed LINC00460 expressions in tissue microarray with 92-paired CRC and adjacent normal tissue samples. A semi-quantitative scoring criterion was used to calculate both the intensity of the positive staining (scores: negative = 0, weak = 1, moderate = 2, or strong = 3) and the proportion of positive cells of interest (scores: 0∼5% = 0, 6%∼25% = 1, 26%∼50% = 2, 51%∼75% = 3, >75%= 4). The product of their scores can be divided into the following categories: negative (scores: 0), weakly positive (scores: 1~4), moderately positive (scores: 5~8), strong positive (scores: 9~12). D. LINC00460 signal was much stronger in CRC samples than that in adjacent tissues samples (P < 0.001). N: Normal C: Cancer. E. Kaplan-Meier survival plots were shown in GEPIA. F. Kaplan-Meier OS and DFS curves were plotted according to the LINC00460 expression level.