Table 2.
Results of the association between ERCC2 and ERCC5 polymorphisms and PCa risk.
| SNP | Comparison | Subgroup | N | PH | PZ | PA | Random | Fixed |
|---|---|---|---|---|---|---|---|---|
| rs13181 | B vs.A | Overall | 11 | 0.820 | 0.679 | 1.000 | 1.014 (0.950-1.082) | 1.014 (0.950-1.082) |
| B vs.A | Asian | 4 | 0.763 | 0.397 | 1.000 | 1.092 (0.894-1.333) | 1.090 (0.893-1.331) | |
| B vs.A | Caucasian | 4 | 0.379 | 0.709 | 1.000 | 0.986 (0.910-1.068) | 0.985 (0.911-1.065) | |
| B vs.A | Other ethnicities | 3 | 0.987 | 0.325 | 1.000 | 1.074 (0.932-1.238) | 1.074 (0.932-1.238) | |
| B vs.A | H-B | 3 | 0.833 | 0.492 | 1.000 | 1.072 (0.883-1.301) | 1.070 (0.881-1.300) | |
| B vs.A | Other | 2 | 0.874 | 0.168 | 1.000 | 1.094 (0.963-1.244) | 1.094 (0.963-1.244) | |
| B vs.A | P-B | 6 | 0.712 | 0.520 | 1.000 | 0.974 (0.897-1.056) | 0.974 (0.897-1.056) | |
| B vs.A | N | 3 | 0.874 | 0.133 | 1.000 | 1.102 (0.971-1.249) | 1.101 (0.971-1.249) | |
| B vs.A | Y | 8 | 0.847 | 0.673 | 1.000 | 0.984 (0.912-1.061) | 0.984 (0.912-1.061) | |
| BA vs.AA | Overall | 11 | 0.999 | 0.412 | 1.000 | 0.962 (0.876-1.056) | 0.962 (0.876-1.056) | |
| BA vs.AA | Asian | 4 | 0.882 | 0.785 | 1.000 | 1.039 (0.798-1.352) | 1.037 (0.797-1.350) | |
| BA vs.AA | Caucasian | 4 | 0.951 | 0.339 | 1.000 | 0.945 (0.841-1.061) | 0.945 (0.841-1.061) | |
| BA vs.AA | Other ethnicities | 3 | 0.913 | 0.756 | 1.000 | 0.970 (0.799-1.177) | 0.970 (0.799-1.177) | |
| BA vs.AA | H-B | 3 | 0.644 | 0.850 | 1.000 | 0.976 (0.753-1.266) | 0.975 (0.752-1.265) | |
| BA vs.AA | Other | 2 | 0.878 | 0.590 | 1.000 | 0.951 (0.793-1.141) | 0.951 (0.793-1.141) | |
| BA vs.AA | P-B | 6 | 0.984 | 0.542 | 1.000 | 0.964 (0.855-1.086) | 0.963 (0.855-1.086) | |
| BA vs.AA | N | 3 | 0.822 | 0.681 | 1.000 | 0.964 (0.808-1.150) | 0.964 (0.808-1.150) | |
| BA vs.AA | Y | 8 | 0.990 | 0.478 | 1.000 | 0.961 (0.861-1.073) | 0.961 (0.861-1.072) | |
| BA+BB vs. AA | Overall | 11 | 0.993 | 0.745 | 1.000 | 0.986 (0.902-1.077) | 0.985 (0.902-1.077) | |
| BA+BB vs. AA | Asian | 4 | 0.848 | 0.579 | 1.000 | 1.076 (0.836-1.385) | 1.074 (0.835-1.382) | |
| BA+BB vs. AA | Caucasian | 4 | 0.895 | 0.431 | 1.000 | 0.957 (0.857-1.068) | 0.957 (0.857-1.068) | |
| BA+BB vs. AA | Other ethnicities | 3 | 0.982 | 0.814 | 1.000 | 1.022 (0.851-1.229) | 1.022 (0.851-1.229) | |
| BA+BB vs. AA | H-B | 3 | 0.741 | 0.839 | 1.000 | 1.027 (0.804-1.312) | 1.026 (0.803-1.310) | |
| BA+BB vs. AA | Other | 2 | 0.867 | 0.805 | 1.000 | 1.022 (0.859-1.216) | 1.022 (0.859-1.216) | |
| BA+BB vs. AA | P-B | 6 | 0.939 | 0.502 | 1.000 | 0.962 (0.859-1.077) | 0.962 (0.859-1.077) | |
| BA+BB vs. AA | N | 3 | 0.838 | 0.694 | 1.000 | 1.035 (0.875-1.225) | 1.034 (0.874-1.225) | |
| BA+BB vs. AA | Y | 8 | 0.981 | 0.532 | 1.000 | 0.967 (0.872-1.073) | 0.967 (0.872-1.073) | |
| BB vs.AA | Overall | 11 | 0.466 | 0.335 | 1.000 | 1.071 (0.927-1.238) | 1.073 (0.930-1.239) | |
| BB vs.AA | Asian | 4 | 0.845 | 0.290 | 1.000 | 1.314 (0.792-2.179) | 1.313 (0.793-2.173) | |
| BB vs.AA | Caucasian | 4 | 0.124 | 0.975 | 1.000 | 1.050 (0.814-1.354) | 0.997 (0.844-1.179) | |
| BB vs.AA | Other ethnicities | 3 | 0.861 | 0.103 | 1.000 | 1.325 (0.941-1.866) | 1.327 (0.944-1.866) | |
| BB vs.AA | H-B | 3 | 0.922 | 0.352 | 1.000 | 1.241 (0.787-1.955) | 1.240 (0.788-1.953) | |
| BB vs.AA | Other | 2 | 0.954 | 0.021 | 0.420 | 1.432 (1.055-1.943) | 1.432 (1.055-1.943) | |
| BB vs.AA | P-B | 6 | 0.556 | 0.587 | 1.000 | 0.952 (0.798-1.135) | 0.953 (0.799-1.135) | |
| BB vs.AA | N | 3 | 0.991 | 0.018 | 0.360 | 1.437 (1.064-1.940) | 1.436 (1.063-1.939) | |
| BB vs.AA | Y | 8 | 0.669 | 0.824 | 1.000 | 0.981 (0.831-1.156) | 0.982 (0.833-1.157) | |
| BB vs. BA+AA | Overall | 11 | 0.357 | 0.179 | 1.000 | 1.118 (0.962-1.300) | 1.096 (0.959-1.252) | |
| BB vs. BA+AA | Asian | 4 | 0.803 | 0.325 | 1.000 | 1.274 (0.785-2.068) | 1.273 (0.787-2.061) | |
| BB vs. BA+AA | Caucasian | 4 | 0.075 | 0.489 | 1.000 | 1.096 (0.845-1.421) | 1.029 (0.883-1.200) | |
| BB vs. BA+AA | Other ethnicities | 3 | 0.796 | 0.068 | 1.000 | 1.354 (0.973-1.883) | 1.357 (0.978-1.884) | |
| BB vs. BA+AA | H-B | 3 | 0.860 | 0.245 | 1.000 | 1.289 (0.831-1.999) | 1.294 (0.838-1.998) | |
| BB vs. BA+AA | Other | 2 | 0.988 | 0.009 | 0.180 | 1.469 (1.100-1.963) | 1.469 (1.100-1.963) | |
| BB vs. BA+AA | P-B | 6 | 0.521 | 0.751 | 1.000 | 0.974 (0.828-1.145) | 0.974 (0.829-1.145) | |
| BB vs. BA+AA | N | 3 | 0.997 | 0.008 | 0.160 | 1.472 (1.107-1.958) | 1.472 (1.106-1.958) | |
| BB vs. BA+AA | Y | 8 | 0.586 | 0.947 | 1.000 | 1.003 (0.861-1.169) | 1.005 (0.863-1.170) | |
| rs1799793 | B vs.A | Overall | 11 | 0.000 | 0.072 | 1.000 | 1.259 (0.980-1.618) | 1.218 (1.138-1.303) |
| B vs.A | Asian | 2 | 0.749 | 0.000 | < 0.001 | 1.539 (1.241-1.907) | 1.537 (1.240-1.906) | |
| B vs.A | Caucasian | 5 | 0.000 | 0.426 | 1.000 | 1.215 (0.752-1.964) | 1.209 (1.113-1.313) | |
| B vs.A | Mixed | 2 | 0.244 | 0.279 | 1.000 | 1.158 (0.845-1.588) | 1.161 (0.886-1.523) | |
| B vs.A | Other ethnicities | 2 | 0.386 | 0.229 | 1.000 | 1.109 (0.935-1.315) | 1.110 (0.937-1.316) | |
| B vs.A | H-B | 5 | 0.174 | 0.024 | 0.480 | 1.191 (0.956-1.484) | 1.217 (1.026-1.445) | |
| B vs.A | Other | 2 | 0.874 | 0.168 | 1.000 | 1.094 (0.963-1.244) | 1.094 (0.963-1.244) | |
| B vs.A | P-B | 4 | 0.000 | 0.215 | 1.000 | 1.497 (0.792-2.832) | 1.285 (1.173-1.407) | |
| B vs.A | N | 3 | 0.080 | 0.071 | 1.000 | 1.198 (0.984-1.459) | 1.156 (1.027-1.301) | |
| B vs.A | Y | 8 | 0.000 | 0.229 | 1.000 | 1.264 (0.863-1.851) | 1.249 (1.150-1.358) | |
| BA vs.AA | Overall | 11 | 0.000 | 0.103 | 1.000 | 1.186 (0.966-1.455) | 1.170 (1.063-1.287) | |
| BA vs.AA | Asian | 2 | 0.030 | 0.481 | 1.000 | 1.286 (0.639-2.591) | 1.269 (0.919-1.751) | |
| BA vs.AA | Caucasian | 5 | 0.000 | 0.235 | 1.000 | 1.242 (0.869-1.777) | 1.222 (1.086-1.375) | |
| BA vs.AA | Mixed | 2 | 0.628 | 0.550 | 1.000 | 1.106 (0.798-1.532) | 1.105 (0.797-1.532) | |
| BA vs.AA | Other ethnicities | 2 | 0.422 | 0.816 | 1.000 | 0.972 (0.769-1.229) | 0.973 (0.770-1.229) | |
| BA vs.AA | H-B | 5 | 0.377 | 0.059 | 1.000 | 1.249 (0.988-1.578) | 1.244 (0.992-1.561) | |
| BA vs.AA | Other | 2 | 0.878 | 0.590 | 1.000 | 0.951 (0.793-1.141) | 0.951 (0.793-1.141) | |
| BA vs.AA | P-B | 4 | 0.000 | 0.277 | 1.000 | 1.287 (0.816-2.030) | 1.276 (1.120-1.453) | |
| BA vs.AA | N | 3 | 0.031 | 0.492 | 1.000 | 1.124 (0.805-1.569) | 1.037 (0.876-1.227) | |
| BA vs.AA | Y | 8 | 0.001 | 0.171 | 1.000 | 1.208 (0.922-1.582) | 1.239 (1.103-1.392) | |
| BA+BB vs. AA | Overall | 11 | 0.000 | 0.075 | 1.000 | 1.264 (0.977-1.636) | 1.239 (1.132-1.355) | |
| BA+BB vs. AA | Asian | 2 | 0.185 | 0.006 | 0.120 | 1.491 (1.020-2.179) | 1.490 (1.119-1.984) | |
| BA+BB vs. AA | Caucasian | 5 | 0.000 | 0.328 | 1.000 | 1.280 (0.781-2.098) | 1.268 (1.135-1.417) | |
| BA+BB vs. AA | Mixed | 2 | 0.421 | 0.381 | 1.000 | 1.152 (0.845-1.572) | 1.150 (0.842-1.570) | |
| BA+BB vs. AA | Other ethnicities | 2 | 0.384 | 0.690 | 1.000 | 1.046 (0.836-1.308) | 1.047 (0.837-1.309) | |
| BA+BB vs. AA | H-B | 5 | 0.279 | 0.028 | 0.560 | 1.255 (0.985-1.597) | 1.267 (1.026-1.564) | |
| BA+BB vs. AA | Other | 2 | 0.867 | 0.805 | 1.000 | 1.022 (0.859-1.216) | 1.022 (0.859-1.216) | |
| BA+BB vs. AA | P-B | 4 | 0.000 | 0.227 | 1.000 | 1.471 (0.786-2.752) | 1.351 (1.196-1.526) | |
| BA+BB vs. AA | N | 3 | 0.038 | 0.265 | 1.000 | 1.188 (0.878-1.606) | 1.117 (0.953-1.310) | |
| BA+BB vs. AA | Y | 8 | 0.000 | 0.191 | 1.000 | 1.279 (0.885-1.850) | 1.300 (1.166-1.450) | |
| BB vs.AA | Overall | 11 | 0.000 | 0.077 | 1.000 | 1.636 (0.948-2.824) | 1.496 (1.287-1.738) | |
| BB vs.AA | Asian | 2 | 0.376 | 0.000 | < 0.001 | 2.066 (1.367-3.123) | 2.089 (1.388-3.145) | |
| BB vs.AA | Caucasian | 5 | 0.000 | 0.508 | 1.000 | 1.423 (0.500-4.044) | 1.416 (1.183-1.695) | |
| BB vs.AA | Mixed | 2 | 0.095 | 0.446 | 1.000 | 1.675 (0.445-6.310) | 1.438 (0.667-3.100) | |
| BB vs.AA | Other ethnicities | 2 | 0.625 | 0.070 | 1.000 | 1.459 (0.965-2.206) | 1.464 (0.969-2.212) | |
| BB vs.AA | H-B | 5 | 0.260 | 0.129 | 1.000 | 1.340 (0.830-2.163) | 1.351 (0.916-1.991) | |
| BB vs.AA | Other | 2 | 0.954 | 0.021 | 0.420 | 1.432 (1.055-1.943) | 1.432 (1.055-1.943) | |
| BB vs.AA | P-B | 4 | 0.000 | 0.240 | 1.000 | 2.297 (0.574-9.200) | 1.560 (1.286-1.892) | |
| BB vs.AA | N | 3 | 0.827 | 0.003 | 0.060 | 1.499 (1.147-1.959) | 1.493 (1.141-1.954) | |
| BB vs.AA | Y | 8 | 0.000 | 0.248 | 1.000 | 1.673 (0.699-4.007) | 1.497 (1.249-1.794) | |
| BB vs. BA+AA | Overall | 11 | 0.000 | 0.087 | 1.000 | 1.533 (0.941-2.497) | 1.388 (1.203-1.603) | |
| BB vs. BA+AA | Asian | 2 | 0.127 | 0.001 | 0.020 | 1.932 (1.058-3.529) | 1.929 (1.313-2.835) | |
| BB vs. BA+AA | Caucasian | 5 | 0.000 | 0.576 | 1.000 | 1.296 (0.523-3.214) | 1.284 (1.081-1.525) | |
| BB vs. BA+AA | Mixed | 2 | 0.101 | 0.371 | 1.000 | 1.644 (0.452-5.979) | 1.413 (0.662-3.019) | |
| BB vs. BA+AA | Other ethnicities | 2 | 0.693 | 0.044 | 0.880 | 1.496 (1.008-2.222) | 1.500 (1.010-2.226) | |
| BB vs. BA+AA | H-B | 5 | 0.301 | 0.327 | 1.000 | 1.218 (0.783-1.893) | 1.205 (0.830-1.751) | |
| BB vs. BA+AA | Other | 2 | 0.988 | 0.009 | 0.180 | 1.469 (1.100-1.963) | 1.469 (1.100-1.963) | |
| BB vs. BA+AA | P-B | 4 | 0.000 | 0.245 | 1.000 | 2.077 (0.606-7.111) | 1.402 (1.166-1.686) | |
| BB vs. BA+AA | N | 3 | 0.998 | 0.003 | 0.060 | 1.462 (1.134-1.886) | 1.463 (1.134-1.887) | |
| BB vs. BA+AA | Y | 8 | 0.000 | 0.269 | 1.000 | 1.557 (0.711-3.410) | 1.355 (1.139-1.612) | |
| rs238406 | B vs.A | Overall | 4 | 0.258 | 0.290 | 1.000 | 1.063 (0.941-1.201) | 1.049 (0.960-1.146) |
| B vs.A | Caucasian | 2 | 0.611 | 0.605 | 1.000 | 1.025 (0.935-1.123) | 1.025 (0.935-1.123) | |
| B vs.A | Other ethnicities | 2 | 0.639 | 0.037 | 0.740 | 1.432 (1.023-2.005) | 1.431 (1.022-2.004) | |
| B vs.A | P-B | 3 | 0.713 | 0.534 | 1.000 | 1.029 (0.940-1.127) | 1.029 (0.940-1.127) | |
| B vs.A | Y | 3 | 0.189 | 0.179 | 1.000 | 1.168 (0.916-1.490) | 1.075 (0.967-1.195) | |
| BA vs.AA | Overall | 4 | 0.418 | 0.335 | 1.000 | 1.074 (0.928-1.243) | 1.074 (0.929-1.243) | |
| BA vs.AA | Caucasian | 2 | 0.251 | 0.525 | 1.000 | 1.040 (0.864-1.251) | 1.051 (0.901-1.226) | |
| BA vs.AA | Other ethnicities | 2 | 0.391 | 0.255 | 1.000 | 1.310 (0.824-2.083) | 1.310 (0.823-2.084) | |
| BA vs.AA | P-B | 3 | 0.517 | 0.515 | 1.000 | 1.051 (0.905-1.221) | 1.051 (0.905-1.221) | |
| BA vs.AA | Y | 3 | 0.563 | 0.137 | 1.000 | 1.137 (0.960-1.346) | 1.137 (0.960-1.346) | |
| BA+BB vs. AA | Overall | 4 | 0.300 | 0.258 | 1.000 | 1.088 (0.913-1.297) | 1.083 (0.943-1.245) | |
| BA+BB vs. AA | Caucasian | 2 | 0.307 | 0.516 | 1.000 | 1.048 (0.901-1.218) | 1.050 (0.907-1.215) | |
| BA+BB vs. AA | Other ethnicities | 2 | 0.377 | 0.102 | 1.000 | 1.456 (0.929-2.280) | 1.454 (0.928-2.280) | |
| BA+BB vs. AA | P-B | 3 | 0.570 | 0.467 | 1.000 | 1.054 (0.914-1.216) | 1.054 (0.914-1.216) | |
| BA+BB vs. AA | Y | 3 | 0.352 | 0.108 | 1.000 | 1.150 (0.959-1.379) | 1.140 (0.972-1.338) | |
| BB vs.AA | Overall | 4 | 0.234 | 0.335 | 1.000 | 1.133 (0.855-1.501) | 1.095 (0.910-1.318) | |
| BB vs.AA | Caucasian | 2 | 0.687 | 0.657 | 1.000 | 1.044 (0.863-1.264) | 1.044 (0.863-1.263) | |
| BB vs.AA | Other ethnicities | 2 | 0.728 | 0.028 | 0.560 | 2.461 (1.084-5.586) | 2.502 (1.105-5.664) | |
| BB vs.AA | P-B | 3 | 0.618 | 0.593 | 1.000 | 1.050 (0.868-1.270) | 1.053 (0.871-1.274) | |
| BB vs.AA | Y | 3 | 0.149 | 0.236 | 1.000 | 1.468 (0.755-2.856) | 1.139 (0.918-1.413) | |
| BB vs. BA+AA | Overall | 4 | 0.410 | 0.559 | 1.000 | 1.045 (0.893-1.224) | 1.048 (0.895-1.227) | |
| BB vs. BA+AA | Caucasian | 2 | 0.790 | 0.848 | 1.000 | 1.016 (0.864-1.194) | 1.016 (0.864-1.194) | |
| BB vs. BA+AA | Other ethnicities | 2 | 0.599 | 0.082 | 1.000 | 1.869 (0.899-3.889) | 1.908 (0.922-3.948) | |
| BB vs. BA+AA | P-B | 3 | 0.640 | 0.788 | 1.000 | 1.020 (0.868-1.199) | 1.022 (0.870-1.201) | |
| BB vs. BA+AA | Y | 3 | 0.237 | 0.629 | 1.000 | 1.197 (0.757-1.891) | 1.047 (0.869-1.262) | |
| rs17655 | B vs.A | Overall | 3 | 0.852 | 0.004 | 0.080 | 1.216 (1.064-1.391) | 1.216 (1.064-1.391) |
| B vs.A | H-B | 2 | 0.578 | 0.040 | 0.800 | 1.226 (1.009-1.489) | 1.226 (1.009-1.489) | |
| B vs.A | Y | 2 | 0.876 | 0.016 | 0.320 | 1.197 (1.034-1.385) | 1.197 (1.034-1.385) | |
| BA G AA | Overall | 3 | 0.889 | 0.066 | 1.000 | 1.187 (0.989-1.424) | 1.187 (0.989-1.424) | |
| BA vs.AA | H-B | 2 | 0.891 | 0.456 | 1.000 | 1.121 (0.830-1.515) | 1.121 (0.830-1.515) | |
| BA vs.AA | Y | 2 | 0.752 | 0.066 | 1.000 | 1.203 (0.988-1.466) | 1.203 (0.988-1.466) | |
| BA+BB vs. AA | Overall | 3 | 0.992 | 0.017 | 0.340 | 1.236 (1.039-1.470) | 1.236 (1.039-1.470) | |
| BA+BB vs. AA | H-B | 2 | 0.922 | 0.164 | 1.000 | 1.224 (0.921-1.626) | 1.224 (0.921-1.626) | |
| BA+BB vs. AA | Y | 2 | 0.901 | 0.028 | 0.560 | 1.234 (1.023-1.489) | 1.234 (1.023-1.489) | |
| BB vs.AA | Overall | 3 | 0.432 | 0.013 | 0.260 | 1.490 (1.082-2.051) | 1.497 (1.089-2.057) | |
| BB vs.AA | H-B | 2 | 0.222 | 0.026 | 0.520 | 1.666 (0.955-2.906) | 1.587 (1.056-2.385) | |
| BB vs.AA | Y | 2 | 0.983 | 0.074 | 1.000 | 1.369 (0.970-1.932) | 1.369 (0.970-1.932) | |
| BB vs. BA+AA | Overall | 3 | 0.363 | 0.028 | 0.560 | 1.382 (1.027-1.860) | 1.389 (1.037-1.861) | |
| BB vs. BA+AA | H-B | 2 | 0.170 | 0.043 | 0.860 | 1.576 (0.870-2.857) | 1.449 (1.012-2.075) | |
| BB vs. BA+AA | Y | 2 | 0.986 | 0.134 | 1.000 | 1.272 (0.928-1.744) | 1.272 (0.928-1.744) |
PH: P value of heterogeneity; PZ: P value of Z test; PA: adjusted P value (PA = PZ *3 polymorphisms * 5 genetic models, and PA<0.05 means statistically significant); A: wild allele; B: mutated allele; HWE: Hardy Weinberg Equilibrium; H-B: hospital-based; P-B: population-based; Y: study conformed to HWE; N: study did not conform to HWE