Table 2.

Diagnostic accuracies of the microRNAs mentioned in the literature.

MicroRNA	Expression	ESCC sample size	Control sample size	Sensitivity (%)	Specificity (%)	AUC	Number of included articles
miR-10a	U	149	100	81.2	80.0	0.886	1
miR-10b	U & D	79	66	79.1	91.8	0.860	2
miR-15a	D	106	106	86.4	100.0	0.951	1
miR-16	U	38	19	94.5	55.8	0.643	1
miR-18a	U	243	209	87.2	97.4	0.870	2
miR-19a	U	89	125	66.3	66.4	0.712	1
miR-20a	U	70	40	64.3	75.0	0.767	1
miR-20b	U	137	155	56.6	67.5	0.627	1
miR-21	U	586	379	88.5	72.0	0.840	7
miR-22	U	149	100	88.6	86.0	0.949	1
miR-24	U	105	30	81.9	83.3	0.866	1
miR-25	U	262	176	72.4	77.0	0.800	3
miR-29c	D	50	50	68.0	68.0	0.720	1
miR-31	U	201	202	86.6	82.2	0.910	2
miR-100	U	217	178	65.5	82.5	0.700	3
miR-106a	U	137	155	77.0	47.4	0.639	1
miR-127-3p	U	149	100	78.5	87.0	0.899	1
miR-129	U	78	23	78.8	73.3	0.792	1
miR-133a	U	149	100	65.1	83.0	0.830	1
miR-138	D	128	40	87.5	69.5	0.871	1
miR-146a	D	154	154	83.9	76.7	0.870	2
miR-148b	U	149	100	66.4	87.0	0.855	1
miR-185	U & D	66	54	96.9	57.5	0.590	2
miR-193a-3p	U	28	28	75.1	87.1	0.851	1
miR-194	U	28	28	65.3	90.1	0.809	1
miR-205	D	50	50	70.0	64.0	0.720	1
miR-216a	D	120	51	80.0	90.2	0.877	1
miR-216b	D	120	51	55.8	90.2	0.756	1
miR-218	D	106	60	71.7	76.7	0.833	1
miR-223	U & D	508	381	73.1	77.1	0.810	4
miR-337-5p	U	28	28	79.1	84.0	0.848	1
miR-365	U	78	23	80.6	86.7	0.831	1
miR-375	U & D	408	2017	85.1	65.3	0.840	4
miR-451	U	128	43	84.4	81.4	0.900	2
miR-483-5p	U	28	28	70.8	74.5	0.739	1
miR-486-5p	U	137	155	55.3	75.8	0.688	1
miR-506	U	110	40	81.2	87.3	0.835	1
miR-584	U	137	155	65.4	63.0	0.659	1
miR-613	D	75	75	81.3	62.7	0.728	1
miR-718	D	120	51	69.2	66.7	0.715	1
miR-1246	U	101	46	71.3	73.9	0.754	1
miR-1297	D	156	156	82.7	84.0	0.900	2
miR-1322	U	201	201	82.1	80.6	0.880	2

Abbreviations: ESCC, esophageal squamous cell carcinoma; AUC, area under the curve; U, up-regulated expression; D, down-regulated expression.