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Ex vivo imaging of major organs at 0.083, 0.25, 1, 4, and 24 h post administration of (A) emulsion and (B) micellar formulations of GDC-0449 and Cy5.5-let-7b in orthotopic pancreatic tumor-bearing NSG mice. In case of the emulsion treated mice, strong Cy5.5 signal was only observed in the kidney whereas micelles treated groups were well distributed in the liver, kidney and tumor.
