Figure 3.

Fluorescence intensity of urine samples and plasma concentration of Cy5.5-let-7b after single tail vein injection of emulsion and micellar formulations carrying CY5.5-let-7b and GDC-0449 in orthotopic pancreatic tumor-bearing mice. At indicated time points (0.083-24 h), the mice were euthanized, major organs were harvested, and urine and plasma was collected. (A) Mean fluorescence intensity in urine was determined using a fluorimeter (n=3). (B) Plasma concentration of Cy5.5-let-7b. (C) Percentage of injected dose of Cy5.5-let-7b. Results are represented as the mean ± S.D. (n=4).