Table 1.
Plasma pharmacokinetic parameters of Cy5.5-let-7b and GDC-0449 after intravenous injection of emulsion and mPEG-b-PCC-g-DC-g-TEPA micellar formulations in orthotopic pancreatic tumor-bearing NSG mice. PK parameters were estimated by non-compartmental analysis using Phoenix WinNonlin software. Results are presented as the mean ± S.D. (n=4).
| Cmax (ng/mL) | AUC0-∞ (ng/mL·h) | CLT (mL/h/kg) | t1/2, e (h) | MRT (h) | VZ (mL/kg) | |
|---|---|---|---|---|---|---|
| Cy5-let-7b emulsion | 1096.71 ± 253.88 | 555.11 ± 38.09 | 3613.83 ± 238.54 | 0.49 ± 0.19 | 0.76 ± 0.29 | 2569.72 ± 557.91 |
| Cy5-let-7b micelles | 1374.48 ± 85.17 | 4091.26 ± 664.71 | 498.90 ± 83.22 | 2.65 ± 0.46 | 3.97 ± 0.68 | 1866.84 ± 45.01 |
| GDC-0449 emulsion | 2164.79 ± 161.09 | 1941.46 ± 27.05 | 5151.51 ± 71.67 | 2.94 ± 0.34 | 2.46 ± 0.40 | 21821.39 ± 2445.30 |
| GDC-0449 micelles | 4207.72 ± 312.78 | 6237.79 ± 397.55 | 1598.56 ± 97.42 | 5.24 ± 0.15 | 5.92 ± 0.32 | 12088.16 ± 915.04 |