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. 2018 Jul 16;8(15):4062–4071. doi: 10.7150/thno.24683

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Scheme 1 — Assembly structure and working principle of NTri-SAAP for cancer theranostics. By conjugating DNA nanotriangle (NTri) scaffold and multiple split activatable aptamer probes (SAAPs) via streptavidin-biotin (SA-Bio) interaction, the NTri-SAAP is assembled. The CG base pair regions allow doxorubicin (Dox) intercalation. In the free state, the NTri-SAAP is a flat, double helix-jointed structure with quenched fluorescence and loaded drugs. Once it encounters the target cell, SAAP can disassemble due to aptamer binding-triggered shape change, thus leading to signal activation and partial drug release. The remaining drugs can then be further freed after internalization.