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. 2016 Nov 12;1(1):43–50. doi: 10.1016/j.ncrna.2016.11.002

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Model of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) regulating expression of HOX genes in trans. LncRNA HOTAIR transcribed from the HOXC cluster of genes (chromosome no.2) binds PRC2 complex of polycomb-group of proteins and targets it to the HOXD cluster (chromosome no.12) leading to H3K27 methylation and silencing of neighboring HOXD genes.