Fig. 2.

miR-199b overexpression results in exaggerated fibrosis in the border zone during post-myocardial infarct remodeling. (a) Representative images of whole hearts (top panels) or wheat-germ agglutinin (WGA)-labeled (lower panels) histological sections, (b) gravimetric analysis of corrected heart weights and (c) quantification of cardiomyocyte surface area of WT or miR-199b transgenic (TG) mice hearts after either 4 weeks of sham or MI surgery. (d) Quantification of infarct sizes in WT and miR-199b transgenic (TG) animals, 4 weeks after MI. (e) Representative images of Sirius red-stained histological sections and (f) quantification of collagen deposition in the border zone of WT or miR-199b transgenic (TG) hearts after MI. n = 6–10, *P < 0.05 (mean ± s.e.m.).