Table 2.

Morphometric and echocardiographic characteristics of mice subjected to 4 weeks of sham or MI and treated either with antagomir-control or antagomir-199b.

	Sham		MI
	Antagomir-control	Antagomir-199b	Antagomir-control	Antagomir-199b
n	13	8	11	11
HW/BW (mg/g)	7.16 ± 0.43	5.65 ± 0.81	8.28 ± 1.03	8.64 ± 0.53
HW/TL (mg/mm)	7.07 ± 0.28	6.47 ± 0.76	9.01 ± 0.43*	9.06 ± 0.67*
LV mass (mg)	95.01 ± 6.51	113.32 ± 6.01	151.71 ± 24.18*	182.29 ± 14.30*
LV mass/BW (mg/g)	4.04 ± 0.22	4.42 ± 0.17	5.58 ± 0.28*	6.93 ± 0.46*#
LV mass/TL (mg/mm)	4.32 ± 0.43	4.97 ± 0.51	6.94 ± 0.23*	7.99 ± 0.33*
IVSd (mm)	0.99 ± 0.03	1.02 ± 0.05	0.84 ± 0.08	0.87 ± 0.08
IVSs (mm)	1.46 ± 0.05	1.49 ± 0.06	1.21 ± 0.10*	1.19 ± 0.10*
LVIDd (mm)	3.70 ± 0.10	3.83 ± 0.12	4.97 ± 0.28*	5.20 ± 0.25*
LVIDs (mm)	2.19 ± 0.12	2.38 ± 0.16	3.91 ± 0.33*	3.55 ± 0.28*
LVPWd (mm)	0.79 ± 0.06	0.92 ± 0.04	0.92 ± 0.07	1.04 ± 0.09*
LVPWs (mm)	1.20 ± 0.05	1.35 ± 0.05	1.23 ± 0.08	1.29 ± 0.07
FS (%)	40.81 ± 2.02	37.85 ± 2.36	21.32 ± 2.69*	31.73 ± 1.74*#
E/A (mm/s)	1.40 ± 0.05	1.24 ± 0.04	1.36 ± 0.07	1.33 ± 0.05

Data are expressed as means ± SEM. HW, heart weight; BW, body weight; TL, tibia length; LV, left ventricular; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole; LVPwd, left ventricular posterior wall thickness at end-diastole; LVPws, left ventricular posterior wall thickness at end-systole; FS, fractional shortening; EF, ejection fraction. *, indicates P < 0.05 vs wt-sham group; #, indicates P < 0.05 vs experimental group.