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. 2017 Jul 26;2(2):119–121. doi: 10.1016/j.ncrna.2017.07.001

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Differential expression of CRNDE transcript variants (TV) and its clinical significance in glioblastoma multiforme. A) CRNDE is located at Chr 16q12.2 and presented with different TV. Corresponding exons are illustrated in boxes with different length. NCBI reference (TV-1: NR_034105.3, TV-2: NR_034106.2, TV-3: NR_110453.1, TV-4: NR_110454.1, TV-5: NM_001308963.1). B) Differential mRNA expressions of TV1-TV5 were detected by qRT-PCR in GBM cell lines (U87 and U138) vs. normal human astrocytes (NHA) and in GBM specimens vs. normal brain tissues. Graphs show the mean ± SD of three independent experiments. **p < 0.001 C) Kaplan Meier survival curve on TV1 and TV5 expression of GBM specimens. Patients were stratified by median expression of TV1 and TV5 into two groups (High or Low).