Table 4.

Regulation of microRNAs by isoquinoline and quinolizidine alkaloids.

Compounds	Tumor suppressors (up-regulated)	Oncogenes (down-regulated)
Berberine	miR-21-3p [83]	miR-21 [80], miR-99a∼125b cluster [84], miR-17∼92 cluster [84], miR-106∼25 cluster [84]
Palmatine chloride	miR-34a [87], miR-141 [87], miR-200c [87]	–
Matrine	–	let-7b-5p [89], miR-10a-5p [89], miR-15b-5p [89], miR-18a-5p [89], miR-19a-3p [89], miR-19b-3p [89], miR-20b-5p [89], miR-21 [88], mir-21-5p [89], miR-23a-3p [89], miR-26b-5p [89], miR-27a-3p [89], miR-27b-3p [89], miR-32-5p [89], miR-34a-5p [89], miR-98 [89], miR-106b-5p [89], miR-181a-5p [89], miR-183-5p [89], miR-338-3p [89]