Table 2.
Role of major lncRNAs in skeletal muscle regeneration.
| lncRNA | Function in muscle regeneration | Experimental design | Ref |
|---|---|---|---|
| CEeRNA | Promotes myogenic differentiation | In vitro loss of function experiments | [136] |
| Dum | Promotes satellite cell differentiation | In vitro and in vivo loss of function experiments | [126] |
| Linc-MD1 | Promotes myogenic differentiation | In vitro gain and loss of function experiments | [160] |
| Linc-MYH | Specification of muscle fibers | In vivo gain and loss of function experiments | [166] |
| Linc-RAM | Promotes myogenic differentiation |
In vitro loss and gain of function experiments; Knock out mice |
[141] |
| Linc-YY1 | Promotes myogenic differentiation |
In vitro gain and loss of function experiments; in vivo loss of function experiments |
[144] |
| Lnc-31 | Promotes myoblast proliferation | In vitro loss of function experiments | [135] |
| LncMyoD | Promotes myoblast differentiation | In vitro loss of function experiments | [138] |
| Malat1 | Promotes myoblasts differentiation | In vitro loss of function experiments | [154] |
| MUNC | Promotes myogenic differentiation |
In vitro gain and loss of function experiments; in vivo loss of function experiments |
[137] |
| Sirt1 AS | Promotes myoblast proliferation | In vitro and in vivo gain of function experiments | [132] |
| SRA | Promotes myogenic differentiation | In vitro gain and loss of function experiments | [139] |
| Yam-1 | Inhibits myogenic differentiation | In vitro and in vivo loss of function experiments | [148] |