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Interaction with and regulation of microRNAs by triterpenes.
| Compound | Tumor suppressors (up-regulated) | Oncogenes (down-regulated) |
|---|---|---|
| Boswellic acids (AKBA) | let-7, miR-34a, miR-200 | miR-27a |
| Betulinic acid | miR-21(!) | miR-27a, miR-33 |
| Ursolic acid | – | miR-21 |
| Glycyrrhetinic acid derivatives | miR-200c | miR-27a |
| Cucurbitacin I | (synergism with miR-337-3p) | miR-21, miR-155 |
| Ginsenosides (Rh2, Rg3) | miR-148a, miR-520h | miR-21, miR-23b, miR-27b, miR-100, miR-221, miR-424 |
