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. 2018 Aug 10;9:314. doi: 10.3389/fgene.2018.00314

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Copyright © 2018 Zhao and Usdin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Difference in repeat number changes in ova and 2-cell embryos. The size of the alleles in each ovum and embryo was determined by nested PCR. Alleles were then analyzed in terms of the change in repeat number relative to the maternal allele. The distribution of the changes in repeat number of expanded allele in embryos is significantly different from the distribution on oocytes (Mann–Whitney; p = 0.001; t-test; p = 0.01), with embryos showing evidence of additional repeats added to the transmitted allele. The difference between ova and embryos with respect to the number of large contractions was also significant (Fisher’s exact test; p = 0.026).