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. 2018 Jul 25;25(1):1579–1584. doi: 10.1080/10717544.2018.1491653

Figure 3.

Figure 3.

(a) Synthesis of chimeric PTD-exendin-4 peptides. TCTP-PTD 13M2 was attached to the N or C-terminus of exendin-4 directly through a peptide bond. (b) Hyperglycemic effect of exendin-4 and attachment of exendin-4 molecules to TCTP-PTD 13M2 in type 2 db/db mice. A single dose of either exendin-4 (2 μg/kg) or chimeric PTD-exendin-4 peptides (equivalent molar dosing) is administered to mice by s.c. injection. The time of glucose challenge in type 2 db/db mice is marked by the arrow. (c) Changes in the glucose response are expressed as the AUC. Vertical bars indicate means ± SEM (n = 6–8). **p < .01 compared with the untreated group; #p < .05 and ##p < .01.