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. 2018 Jul 3;6(4):293–303. doi: 10.1007/s40336-018-0289-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — a Averaged time activity curves and b representative short-axis images of in vivo rabbit cardiac PET imaging. Desipramine (DMI) chase (i.e., DMI administered after tracer delivery) enhanced ¹¹C-Hydroxyephedrine (¹¹C-HED) tracer washout, while ¹⁸F-LMI1195 washout remained stable. c Results of in vivo rabbit ¹²³I-metaiodobenzylguanidine (¹²³I-mIBG) planar scintigraphy of the chest. Similar to ¹⁸F-LMI1195, DMI chase did not change cardiac distribution of ¹²³I-mIBG. This might be due to the underlying benzylguanidine structure shared by both radiotracers. Dotted lines indicate regions of interest in both heart and mediastinum.

Modified from Werner et al. [35] © by the Society of Nuclear Medicine and Molecular Imaging, Inc.