Fig. 8.

Midzone formation. Midzone formation is mediated by microtubules (MT), passing the arms of separating chromatids and withdrawing chromatin from the telomere regions. Chromosomal passenger complexes (CPC) such as Aurora B, INCENP, borealin and survivin, translocate in anaphase-A from the centromeres to the ends of the chromosomes. Accumulation of CPCs in the midzone is initiated, where antiparallel microtubules overlap. With attachment of VTCs to accumulated CPCs, clamps are formed. Simultaneously, with anaphase progression chromatin strands relocate to their chromosomes, which are pulled to the centrosomes by microtubules, attached to kinetochore (K), whereas clamps remain in the midzone