Table 2.
Severity of hippocampal calcification in relation to risk factors
| Determinant | Absent, n = 749 | Mild, n = 188 |
Moderate, n = 139 |
Severe, n = 54 |
p value |
|---|---|---|---|---|---|
| Age, years (median, IQR) | 67.2 (21) | 69.6 (17) | 70.3 (15) | 74.0 (17) | < .01 |
| Gender (male) | 426 (56.8) | 109 (58.3) | 76 (54.7) | 32 (59.3) | .92 |
| Stroke in medical history | 162 (21.6) | 53 (28.3) | 40 (29.2) | 21 (38.9) | < .01 |
| Hypertension | 388 (51.7) | 99 (53.2) | 77 (55.8) | 32 (61.5) | .548 |
| Diabetes mellitus | 92 (12.3) | 36 (19.3) | 32 (23.3) | 11 (20.4) | < .01 |
| Hyperlipidaemia | 223 (30.5) | 83 (45.1) | 57 (43.5) | 25 (49.0) | < .01 |
| Smoking | .22 | ||||
| Current | 201 (28.7) | 43 (25.1) | 38 (29.5) | 21 (42.9) | |
| Former | 223 (31.8) | 66 (38.4) | 42 (32.6) | 15 (30.6) | |
| Never | 227 (39.5) | 62 (36.6) | 49 (38.0) | 13 (26.5) | |
| Obesity, BMI > 30 | 98 (21.1) | 32 (24.4) | 14 (17.7) | 2 (5.6) | .08 |
| eGFR < 60 | 112 (15.0) | 20 (14.5) | 9 (16.7) | 39 (15.2) | .94 |
| 1st degree family < 60 years with CVD history | 168 (32.6) | 32 (27.1) | 37 (42.0) | 8 (32.0) | .16 |
IQR interquartile range, CVD cardiovascular disease, eGFR estimated glomerular filtration rate [ml/min/1.73 m2, = 32,788 × (serum creatinine)−1.154 × (age)−0.203 × (0.742 if woman) × (1.210 if black)], BMI body mass index in kg/m2, data presented as n (%)