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. 2018 Jul 3;61(9):2016–2029. doi: 10.1007/s00125-018-4672-5

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — (a) At 500 IEQ, glucose clearance was significantly improved in the P1000 group (n = 9) compared with the native islet groups (*p < 0.05 at 60 min, n = 10). There was significant impairment in the glucose clearance in the mice transplanted with the native islets compared with the naive non-diabetic control mice (††p < 0.01 at 60 and 120 min, †††p < 0.001 at 90 min, n = 4); this impairment was not, however, mirrored in the P1000 group. There was no significant difference between the P750 (n = 9) and P500 (n = 8) groups at any time during the IPGTT. (b) At 1000 IEQ, glucose clearance was significantly improved in the P1000 group at 60 min (**p < 0.01, n = 9) compared with the native islet transplant group (n = 9). There was no significant difference between the P750 (n = 10) and P500 (n = 8) groups compared with animals transplanted with native islets at any time during the IPGTT. (a, b) Dark green line and symbols, P1000; light green line and symbols, P750; blue line and symbols, P500; black dashed line, native islets; grey line, non-diabetic control mice. (c, d) When comparing the AUC (c, at 500 IEQ; d, at 1000 IEQ), differences in overall glucose clearance in the mice transplanted with native islets vs those transplanted with CFA-PI did not reach statistical significance. Mice regardless of euglycaemia were compared (unpaired t test between groups at each time point corrected for multiple comparison using the Holm–Sidak method; analysis of AUC by one-way ANOVA with Tukey’s multiple comparisons)