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. 2018 Aug 14;32:2058738418781634. doi: 10.1177/2058738418781634

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — IL-21R overexpression weakened OMT-mediated inactivation of JAK2/STAT3 signaling pathway. (a) CCK-8 assay indicated that IL-21R overexpression reversed the anti-proliferation effects of OMT in HGC-27 and AGS cell lines. (b) Transwell assay indicated that IL-21R overexpression reversed the anti-invasion effects of OMT. (c) Western blotting indicated that IL-21R overexpression decreased the inhibitory effects of OMT on the protein expression levels of JAK2/STAT3 signaling. Data are the means ± SEM of three experiments. *P < 0.05; **P < 0.01.

NC: the empty vector; IL-21R: overexpression of IL-21R. And the concentration of OMT is 4 mg/mL.