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. 2018 Aug 14;14:1744806918783478. doi: 10.1177/1744806918783478

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — The protein expression of GABA_A receptor subunits was not altered in the ACC. (A) Western blotting analysis of GABA_A receptor subunit expression. Synapsin I, gephyrin, and calnexin were used as presynaptic, postsynaptic (GABAergic), extrasynaptic, and ILM fraction markers, respectively. (B) Comparison of relative expression of GABA_A receptor subunits between control and CFA in all fractions. In the presynaptic fraction of CFA group, the relative value of α5 was 1.15 ± 0.13 of control group. In the postsynaptic fraction of CFA group, the relative values of α1, α5, β2, and γ2 were 1.02 ± 0.08, 1.04 ± 0.23, 1.16 ± 0.07, and 1.13 ± 0.09 of control, respectively. In the extrasynaptic fraction of CFA group, the relative values of α5 and δ were 0.85 ± 0.10 and 1.10 ± 0.02 of control group. In ILM of CFA group, the relative values of α5 and β2 were 1.07 ± 0.05 and 0.93 ± 0.08 of control group. Three independent experiments were performed, and the results are expressed as the mean ± SEM.

CFA: complete Freund adjuvant; ILM: intracellular light membrane; GABA: γ-aminobutyric acid.