Fig. 2.

Persistence with denosumab at 12 and 24 months. a Percentage of patients who were persistent with denosumab at 12 and 24 months. The primary analysis set included patients who received at least two denosumab injections (12-month persistence) or four denosumab injections (24-month persistence), with an injection interval of no longer than 6 months plus 8 weeks. b Sensitivity analysis of 24-month persistence. Sensitivity analyses were done to evaluate whether persistence is affected by varying the time interval between injections—6 months plus 4 weeks, 6 months plus 6 weeks, or 6 months plus 12 weeks. Error bars represent 95% confidence intervals