Table 1.
Characteristics | USA (N = 632) | Canada (N = 303) | Overall (N = 935) |
---|---|---|---|
Age, years, mean (SD) | 71.9 (10.0) | 68.6 (9.2) | 70.8 (9.9) |
Age group, years, n (%) | |||
< 65 | 152 (24) | 115 (38) | 267 (29) |
≥ 65 to < 75 | 216 (34) | 102 (34) | 318 (34) |
≥ 75 | 264 (42) | 86 (28) | 350 (37) |
Race, n (%) | |||
White | 601 (95) | 285 (94) | 886 (95) |
Asian | 9 (1) | 16 (5) | 25 (3) |
Black or African American | 9 (1) | 0 (0) | 9 (1) |
Othera | 13 (2) | 2 (0.7) | 15 (2) |
Body mass index, kg/m2 | |||
Mean (SD) | 25.5 (5.7) | 26.1 (5.1) | 25.7 (5.5) |
≤ 25 | 351 (56) | 127 (42) | 478 (51) |
> 25 | 269 (43) | 155 (51) | 424 (45) |
Missing | 12 (2) | 21 (7) | 33 (4) |
Modified Wolfe comorbidity index, median (Q1, Q3) | 2.0 (1.0, 3.0) | 2.0 (1.0, 3.0) | 2.0 (1.0, 3.0) |
Number of prescription medications taken at baseline, median (Q1, Q3) | 8.0 (5.0, 11.0) | 5.0 (3.0, 7.0) | 7.0 (4.0, 10.0) |
Lumbar spine T-score | |||
Mean (SD) | − 1.9 (1.4) | − 2.1 (1.3) | − 2.0 (1.3) |
≤ − 2.5, n (%) | 221 (40) | 115 (46) | 336 (42) |
> − 2.5, n (%) | 328 (60) | 134 (54) | 462 (58) |
Femoral neck T-score | |||
Mean (SD) | − 2.3 (0.8) | − 1.9 (1.0) | − 2.2 (0.9) |
≤ − 2.5, n (%) | 262 (47) | 69 (28) | 331 (41) |
> − 2.5, n (%) | 300 (53) | 176 (72) | 476 (59) |
History of fractureb, n (%) | 325 (51) | 145 (48) | 470 (50) |
Vertebral | 104 (16) | 45 (15) | 149 (16) |
Nonvertebralc | 271 (43) | 120 (40) | 391 (42) |
Time since the most recent osteoporotic fracture, n (%) | |||
< 12 months | 40 (6) | 23 (8) | 63 (7) |
≥ 12 months | 283 (45) | 122 (40) | 405 (43) |
Parental history of hip fracture, n (%) | 127 (20) | 69 (23) | 196 (21) |
Osteoporosis medication | |||
Any exposure to osteoporosis therapy prior to enrollment, n (%) | 587 (93) | 280 (92) | 867 (93) |
Use of osteoporosis therapy > 5 years prior to enrollment, n (%) | 360 (57) | 187 (62) | 547 (59) |
Number of prior osteoporosis medications taken, mean (SD) | 2 (1.3) | 2 (1.2) | 2 (1.3) |
Q1, Q3 means interquartile range
SD standard deviation
aOther includes mixed race, American Indian or Alaska Native, Native Hawaiian or other Pacific Islander, or others (not specified)
bExcludes fractures not associated with decreased bone mineral density (skull, face, mandible, metacarpals, fingers, toes, and cervical vertebrae), pathologic fractures, and fractures associated with severe trauma (defined as a fall from a height higher than a stool, chair, or first rung of a ladder, or severe trauma other than a fall)
cIncludes fractures of the pelvis, hip, lower leg (not knee or ankle), ribs, shoulder, forearm, and wrist and excludes pathologic fractures and fractures associated with severe trauma