Fig. 1.

Inhibition of whole cell G. vaginalis sialidase by Zanamivir (10 mM). Whole bacteria (strains as indicated) were incubated with Zanamivir in the presence of MU-NANA (0.2 mM) as described for 1 h. Sialidase activity was measured using readings of fluorescence (excitation 370 nm emission 420 nm). Activity was calculated as a percentage of sialidase activity seen with no inhibitor (Con). Assays were conducted at a pH 7.4 and pH 5.5 as indicated. Students’ t test was used to calculate significant differences between con and drug, and noted in A (n = 3). Error bars are ± standard error of the mean (SEM).

Fig produced using GraphPad Prism