Table 3.
Proportion (%) of sham-transfected (left) and forced Kv7.2/7.3 co-expressing (right) CTR33Qn1-derived neurons which demonstrated each of the different types of induced action potentials during weeks 1 (upper), 2 (middle) and 3 (lower) weeks of neuronal differentiation post-plate down in vitro
| Week | Induced action potential type | Sham transfected | + Kv7.2/7.3 | ||
|---|---|---|---|---|---|
| Proportion | % | Proportion | % | ||
| 1 | None | 1/17 | 6 | 0/16 | 0 |
| Attempting single | 0/17 | 0 | 0/16 | 0 | |
| Single | 5/17 | 29 | 4/16 | 25 | |
| Attempting train | 1/17 | 6 | 3/16 | 19 | |
| Train | 10/17 | 59 | 9/16 | 56 | |
| 2 | None | 0/12 | 0 | 0/11 | 0 |
| Attempting single | 0/12 | 0 | 0/11 | 0 | |
| Single | 3/12 | 25 | 2/11 | 18 | |
| Attempting train | 1/12 | 8 | 2/11 | 18 | |
| Train | 8/12 | 67 | 7/11 | 64 | |
| 3 | None | 0/12 | 0 | 0/11 | 0 |
| Attempting single | 0/12 | 0 | 0/11 | 0 | |
| Single | 3/12 | 25 | 0/11 | 0 | |
| Attempting train | 0/12 | 0 | 0/11 | 0 | |
| Train | 9/12 | 75 | 0/11 | 100 | |
None = no significant voltage excursions from baseline; Attempting single = voltage excursions which do not overshoot 0 mV; Single = one excursion only, but which overshoots 0 mV; Attempting train = several excursions, but only one which overshoots 0 mV; Train = several excursions, with more than one which overshoots 0 mV