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. 2018 Apr 23;207(3):211–225. doi: 10.1007/s00430-018-0542-5

Table 3.

Enzymes significantly over- or underrepresented in the colorectal cancer and control samples (p < 0.05)

Enzymes EC p values Control CRC Ratio Fold change
Overrepresented in the Control Samples
 O-Succinylbenzoic acid–CoA ligase EC:6.2.1.26 0.0127 0.6 3.2 0.2 −1.5
 Acid phosphatase (class A) EC:3.1.3.2 0.0178 0.7 4.3 0.1 − 1.7
 Carbonic anhydrase EC:4.2.1.1 0.021 0.6 3.1 0.2 − 1.5
 Ribonucleoside-diphosphate reductase beta chain EC:1.17.4.1 0.0247 0.6 3.0 0.2 − 1.5
 Alpha-amylase EC:3.2.1.1 2 0.0337 0.6 3.1 0.2 − 1.5
 lysozyme EC:3.2.1.17 0.0337 0.7 3.7 0.1 − 1.6
 Carbonyl reductase (NADPH) EC:1.1.1.184 0.0385 0.9 11.2 0.08 − 2.5
 Dipeptidase E EC:3.4.13.21 0.0392 0.6 2.7 0.2 − 1.4
 Naphthoate synthase EC:4.1.3.36 0.0392 0.6 3.1 0.2 − 1.5
 Putative metalloprotease EC:3.4.24.- 0.0392 0.7 3.6 0.1 − 1.6
 Isochorismate synthase EC:5.4.4.2 0.0455 0.6 3.2 0.2 − 1.5
 Phosphatidylethanolamine N-methyltransferase EC:2.1.1.17 0.0478 0.9 44.4 0.02 − 3.8
 2-Hydroxy-3-oxopropionate reductase EC:1.1.1.60 0.0289 0.4 1.7 0.2 − 1.4
Overrepresented in the Colorectal Cancer Samples
 2-Dehydro-3-deoxygalactonokinase EC:2.7.1.58 0.0106 0.4 1.7 0.2 − 1.4
 2-Phosphosulfolactate phosphatase EC:3.1.3.71 0.0246 0.2 1.2 0.1 − 1.7
 3-Dehydro-l-gulonate 2-dehydrogenase EC:1.1.1.130 0.0247 0.4 1.7 0.2 − 1.4
 3-Hydroxybutyryl-CoA dehydratase EC:4.2.1.55 0.021 0.3 1.5 0.2 − 1.4
 5-Methylthioadenosine/S-adenosylhomocysteine deaminase EC:3.5.4.- 3.5.4.28 0.0455 0.3 1.5 0.2 − 1.4
 Acetaldehyde dehydrogenase (acetylating) EC:1.2.1.10 0.0335 0.5 2.1 0.2 − 1.3
 Acetate CoA-transferase alpha subunit EC:2.8.3.8 0.0247 0.4 1.9 0.2 − 1.3
 Acetyl-CoA synthetase (ADP-forming) EC:6.2.1.13 0.0384 0.8 5.3 0.1 − 1.8
 Acetylglutamate kinase EC:2.7.2.8 0.0337 0.4 1.6 0.2 − 1.4
 Acyl-CoA dehydrogenase EC:1.3.99.- 2 0.0023 0.1 1.1 0.08 − 2.4
 Adenylate cyclase, class 2 EC:4.6.1.1 0.0221 0.3 1.5 0.2 − 1.4
 Alanine-synthesizing transaminase EC:2.6.1.- 0.0454 0.3 1.5 0.2 − 1.4
 Aminotransferase EC:2.6.1.- 2 0.0106 0.3 1.5 0.2 − 1.5
 Arginine decarboxylase EC:4.1.1.19 4 0.0023 0.2 1.3 0.1 − 1.6
 Asparagine synthase (glutamine-hydrolysing) EC:6.3.5.4 0.0392 0.3 1.6 0.2 − 1.4
 Aspartate aminotransferase EC:2.6.1.1 4 0.0151 0.3 1.5 0.2 − 1.4
 Beta-glucosidase EC:3.2.1.21 2 0.0455 0.4 1.7 0.2 − 1.4
 Beta-phosphoglucomutase EC:5.4.2.6 0.021 0.3 1.5 0.2 − 1.4
 Butyryl-CoA dehydrogenase EC:1.3.8.1 0.021 0.3 1.4 0.2 − 1.5
 C4-Dicarboxylate-binding protein DctP 0.0035 0.2 1.3 0.1 − 1.6
 Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha EC:1.2.7.4 1.2.99.2 2.3.1.169 0.021 0.2 1.4 0.2 − 1.5
 Carbon-monoxide dehydrogenase gamma subunit EC:1.2.99.2 0.0337 0.3 1.4 0.2 − 1.5
 Cell division inhibitor SepF 0.0455 0.3 1.5 0.2 − 1.4
 Chemotaxis protein CheD EC:3.5.1.44 0.0015 0.1 1.2 0.1 − 1.8
 Chemotaxis protein methyltransferase CheR EC:2.1.1.80 0.0074 0.2 1.3 0.1 − 1.6
 Cyanophycinase EC:3.4.15.6 0.0067 0.01 1.01 0.01 − 4.1
 Cysteine desulfurase EC:2.8.1.7 0.0247 0.3 1.5 0.2 − 1.4
 Cystine transport system ATP-binding protein EC:3.6.3.- 0.0337 0.3 1.5 0.2 − 1.4
 D-proline reductase (dithiol) PrdE EC:1.21.4.1 0.0422 0.3 1.5 0.2 − 1.4
 Dihydroflavonol-4-reductase EC:1.1.1.219 0.0074 0.2 1.3 0.1 − 1.7
 Fatty acid synthase, bacteria type EC:2.3.1.- 0.002 0.04 1.04 0.04 − 3.1
 Flagellar assembly factor FliW 0.0015 0.1 1.2 0.1 − 1.9
 Flagellar assembly protein FliH 0.0056 0.2 1.2 0.1 − 1.7
 Flagellar biosynthesis protein 0.0062 0.2 1.3 0.1 − 1.6
 Flagellar hook protein FlgE 0.0151 0.2 1.3 0.1 − 1.6
 Flagellar protein FlaG 0.0074 0.2 1.2 0.1 − 1.7
 Fructose-6-phosphate aldolase 2 EC:4.1.2.- 0.0089 0.3 1.5 0.2 − 1.4
 Galactonate dehydratase EC:4.2.1.6 0.0178 0.2 1.3 0.1 − 1.6
 Glucoamylase EC:3.2.1.3 0.0305 0.05 1.05 0.05 − 2.9
 Glucose 1-dehydrogenase EC:1.1.1.47 0.0046 0.2 1.2 0.1 − 1.7
 Glutamate formiminotransferase EC:2.1.2.5 0.0392 0.4 1.8 0.2 − 1.3
 Glutamate synthase (ferredoxin) EC:1.4.7.1 0.0178 0.3 1.5 0.2 − 1.4
 Glutamine amidotransferase EC:2.4.2.- 0.0392 0.3 1.6 0.2 − 1.4
 Glycerol kinase EC:2.7.1.30 0.0392 0.3 1.5 0.2 − 1.4
 Glycine reductase EC:1.21.4.2 0.0023 0.2 1.3 0.1 − 1.6
 Histidinol-phosphatase (PHP family) EC:3.1.3.15 0.0106 0.3 1.5 0.2 − 1.4
 Inosose isomerase EC:5.3.99.- 0.0392 0.3 1.4 0.2 − 1.5
 l-Asparagine permease 0.0287 0.6 3.08 0.2 − 1.5
 Lipopolysaccharide transport system permease protein 0.021 0.4 1.7 0.2 − 1.4
Mannonate dehydratase EC:4.2.1.8 0.0455 0.4 1.8 0.2 − 1.3
 Methyl-galactoside transport system substrate-binding protein 0.0151 0.3 1.5 0.2 − 1.4
 Motility quorum-sensing regulator/GCU-specific mRNA interferase toxin 0.021 0.03 1.03 0.03 − 3.4
 N-Acetylglucosamine-6-phosphate deacetylase EC:3.5.1.25 0.0392 0.4 1.7 0.2 − 1.4
 N-Glycosylase/DNA lyase EC:3.2.2.- 4.2.99.18 2 0.0089 0.2 1.3 0.2 − 1.5
 Ornithine carbamoyltransferase EC:2.1.3.3 0.0289 0.3 1.5 0.2 − 1.4
 Phosphatidylglycerol:prolipoprotein diacylglycerol transferase EC:2.-.-.- 0.0289 0.3 1.5 0.2 − 1.4
 Purine catabolism regulatory protein 0.0178 0.4 1.7 0.2 − 1.4
 Putative glutamine amidotransferase 0.0074 0.2 1.4 0.2 − 1.5
 Pyrimidine-specific ribonucleoside hydrolase EC:3.2.-.- 0.0247 0.3 1.5 0.2 − 1.4
 Pyruvate ferredoxin oxidoreductase, alpha subunit EC:1.2.7.1 0.0089 0.2 1.2 0.1 − 1.7
 Serine/threonine-protein kinase Stk1 EC:2.7.11.- 0.047 0.03 1.03 0.03 − 3.3
 Sirohydrochlorin cobaltochelatase EC:4.99.1.3 2 0.0283 0.04 1.05 0.04 − 3.07
 Superoxide dismutase EC:1.15.1.1 0.0162 0.1 1.2 0.1 − 1.8
 Threonine 3-dehydrogenase EC:1.1.1.103 0.0392 0.4 1.7 0.2 − 1.4
 Two-component system, AgrA family, sensor histidine kinase AgrC EC:2.7.13.- 0.0455 0.3 1.4 0.2 − 1.5
 Two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP 0.0178 0.3 1.5 0.2 − 1.4
 UDP-N-acetyl-d-glucosamine dehydrogenase EC:1.1.1.- 0.0138 0.1 1.1 0.09 − 2.3
 Virulence factor 0.0289 0.2 1.3 0.1 − 1.6
 Xanthine phosphoribosyltransferase EC:2.4.2.22 0.0488 0.5 2.3 0.2 − 1.4