FIG 1.

Virus titers in tear film and neural tissues after corneal inoculation. Groups of BALB/c mice were inoculated on their scarified corneas with 2 × 10⁵ PFU per eye of wild-type KOS, KOS-NA, or ICP0⁻ (7134) virus. (A) Titers of virus collected on corneal swabs were determined 4 h and 1 to 4 days postinfection. **, P = 0.0083, and ***, P = 0.0009 for KOS-NA compared with KOS (P > 0.05 for KOS-NA compared with ICP0⁻ virus). (B) Mice were euthanized on day 5 postinfection, and viral titers in TG and brainstems were determined. The values represent means and standard errors of the mean (SEM) of a total of 6 to 10 mice per group compiled from 2 independent experiments. ***, P < 0.0001 for KOS-NA or ICP0⁻ virus compared with KOS. The dashed lines indicate limits of detection.