TABLE 3.
Sequence conservation of 13D4 epitope residues in all H5 isolatesa
| Position | Amino acid type (%) |
|
|---|---|---|
| 13D4 epitope residue | Other | |
| 131 | E (71.0) | D (25.0), Y/N/T/G (4.0) |
| 133a | L (33.8) | S (58.5), M/G/K/A/V/P (7.7) |
| 136 | S (99.4) | T/R/G (0.6) |
| 137 | S (75.1) | A (24.6), P/T/L/V (0.3) |
| 153 | W (100) | |
| 155 | I (86.7) | T (11.7), V/L/N (1.6) |
| 156 | K (99.3) | E/Q/R/N/T/I/G (0.7) |
| 158 | N (75.5) | D (22.8), S/G/Q/E/Y/I/K (1.7) |
| 159 | S (19.0) | N (64.0), D (16.1), T/A/H/G (0.9) |
| 186 | N (99.0) | S/K/T/A/D/I (1.0) |
| 187 | D (87.9) | N (11.1), H/G/S/Y (1.0) |
| 190 | E (99.7) | K/H/A/D/V (0.3) |
| 193 | K (50.0) | R (38.4), N (6.9), M/D/T/G/QE/Q/S (4.7) |
| 194 | L (95.5) | I (4.3), V/F/S (0.2) |
| 222 | K (89.3) | Q (9.0), R/E/P/N (1.7) |
| 226 | Q (99.7) | L/R/K/P (0.3) |
| Avg | 82.8 | |
a
The cumulative number deposited in the NCBI Influenza Database by 2016 was 5,693.