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. 2018 Jul 30;35(9):182. doi: 10.1007/s11095-018-2458-6

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Total hepatic plasma clearance versus body weight for children in our study (○) and calculated plasma clearance in adults () based on the reported typical hepatic whole-organ intrinsic clearance of 1640 L/h, a hepatic blood flow increasing with body weight (Q_h = 3.75∙WT^0.75), a fraction unbound of 0.0303 and a blood: plasma ratio of 0.66 (13) using eq. 15.

Inline graphic — Total hepatic plasma clearance versus body weight for children in our study (○) and calculated plasma clearance in adults () based on the reported typical hepatic whole-organ intrinsic clearance of 1640 L/h, a hepatic blood flow increasing with body weight (Q_h = 3.75∙WT^0.75), a fraction unbound of 0.0303 and a blood: plasma ratio of 0.66 (13) using eq. 15.