Fig. 2.

Miros in mitochondrial movement. The Miros act within an integrated machinery with TRAK1/2 to facilitate the anterograde and retrograde movement of mitochondria along microtubules. Both axonal and dendritic mitochondrial transport are mediated by the Miros, although they appear to engage different transport machineries to achieve this. TRAK1 binds to both kinesin-1 and dynein/dynactin and is predominantly localised in axons, while TRAK2 preferentially binds dynein/dynactin and exhibits dendritic localization. The interaction of TRAK1 with both the kinesin (anterograde) and dynein (retrograde) motors enable movement in both directions in the axon, while TRAK2’s more favourable interactions with dynein may encourage retrograde movement at neurons’ distal ends. Only the anterograde movement is shown in this figure. Miro EF-hands are represented by yellow rectangles; calcium is represented by red spheres. The molecules and mitochondria are not depicted to scale