Figure 6.

The effect of geometry and topography on cell fate decisions. a) Schematic image shows how cells sense sharp curvature. b) Cell spreading area determines stem cell differentiation. Reproduced with permission.56 Copyright 2004, Cell Press. c) Differentiation of hMSCs is determined by cell contractility triggered by different geometries. Reproduced with permission.57 Copyright 2010, National Academy of Sciences (United States). d) Cell spreading area directs YAP/TAZ localization. Reproduced with permission.18 Copyright 2011, Nature Publishing Group. e) Cell spreading area determines nuclear lamin localization. Reproduced with permission.19 Copyright 2015, Nature Publishing Group. f) Substrates with spatially organized multiple adhesive ligands patterns can be used for investigating the effect of various integrin bindings on cell adhesion and migration. Reproduced with permission.58 Copyright 2011, Royal Society of Chemistry (United Kingdom). g) With the increase of pillar height, nucleus was deformed, FAs and actin cytoskeletons were densely distributed around the micropillars and became obscure. Reproduced with permission.59 Copyright 2016, Elsevier. h) Geometry determines tissue growth rate. Reproduced with permission.60 Copyright 2008, The Royal Society (United Kingdom). i) Geometric cues affect cell proliferation rate. Reproduced with permission.61 Copyright 2005, National Academy of Sciences (United States).