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. 2018 May 22;27(17):2955–2964. doi: 10.1093/hmg/ddy193

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Figure 1. — Identification and characterization of age-dependent DhMRs in ASD cerebellum. (A) The number of 5hmC reads in each 20 kb bin of hg19 were analyzed between ASD and control samples to find DhMRs. Only 797 DhMRs (q-value < 0.05, FDR adjusted) were found in the young group (n = 5), while no DhMR was found in the middle (n = 6–8), old (n = 6), or random groups (two samples were randomly chosen from each age group; n = 6). (B) Genomic annotation of 797 DhMRs to show their percentage of each genomic region. (C) Chromosomal distribution of DhMRs. When compared with control samples, 71% of the DhMRs show reduced 5hmC level (Log2FC < 0) in ASD samples.