Table 5.

Association between gene expression, methylation, and urine arsenic level in occupational exposure group

	As(III) (μg/g creat.)		5-mC %		NRF2, KEAP1 promoter methylation		As(III) (μg/g creat.) adj. global methylation		As(III) (μg/g creat.) adj. NRF2, KEAP1 promoter methylation
	R	p	R	p	R	p	B	p	B	p
NRF2-dCT	0.35	0.0061	0.20	0.1218	− 0.21	0.1004	0.11	0.0067	0.08	0.0324
KEAP1-dCT	0.32	0.0133	0.25	0.0494	− 0.03	0.8469	0.09	0.0217	0.10	0.0090
HMOX1-dCT	0.36	0.0051	0.28	0.0324			0.08	0.0211
GSTP1-dCT	0.27	0.0348	0.06	0.6256			0.07	0.0288
NQO1-dCT	0.22	0.0949	0.26	0.0449			0.06	0.2194
PRDX1-dCT	0.30	0.0184	0.06	0.6689			0.08	0.0271
TRXR1-dCT	0.39	0.0019	0.18	0.1728			0.10	0.0159

R, correlation coefficient; B, interpretation as R