Fig. 6.
Inhibitory effect of PL on LPS-induced amyloidogenesis and neuroinflammation in cultured brain cells. The expressions of amyloidogenesis proteins, such as APP and BACE1, were detected by Western blotting using specific antibodies in the astrocyte primary (a) and microglial BV-2 cells (b). The levels of Aβ1−42 in the astrocyte primary (c) and microglial BV-2 cells (d) were measured by ELISA. Data are expressed as the mean ± S.E.M. (t test, *p < .05 vs. control, #p < .05 vs. LPS). The expressions of neuroinflammation proteins, such as iNOS, COX-2 and GFAP, were detected by Western blotting using specific antibodies in the astrocyte primary (e) in the microglial BV-2 cells (f). Each blot is representative of three experiments