Table 4.

Multivariate analysis

	Odds ratio	95%CI	p
Age
≥ 75 years	0.691	0.3876–1.2320	0.2104
< 75 years	1
Sex
Male	0.6541	0.3820–1.1200	0.1218
Female	1
Prior line
3 ≤	2.012	1.2220–3.3130	0.006019
1–2	1
Histology
Squamous	1.36	0.8401–2.2000	0.2111
Non-squamous	1
C-reactive protein
≥ 1	0.973	0.5521–1.7150	0.9246
< 1	1
irAEs
+	0.5785	0.3404–0.9831	0.04309
–	1
NLR 2 weeks
≥ 3	1.368	0.7600–2.4630	0.2959
< 3	1
NLR 4 weeks
≥ 3	1.595	0.9278–2.7430	0.0912
< 3	1

irAE immune-related adverse event, NLR neutrophil-to-lymphocyte ratio