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. 2018 Aug 8;24:5501–5508. doi: 10.12659/MSM.907439

Figure 4.

Figure 4

Overexpression of IL-6 increased immunosuppression in CRC mouse models. (A) Gating plots for MDSCs are shown. (B, C) In IL-6 overexpressed tumors, the frequency of MDSCs were significantly increased. However, in the IL-6-deficient tumors, their ratios were significantly decreased. (D, E) The number of Tregs was increased in IL-6-overexpressed tumors. (F, G): Tumors with IL-6 overexpression showed increased PD-L1 expression but tumors with IL-6 deficiency showed decreased PD-L1 expression. ** P value less than 0.01; *** P value less than 0.001; **** P value less than 0.0001; WT – wild-type; EV – empty vector; OE – overexpression; MDSCs – myeloid-derived suppressor cells; Tregs – regulatory/suppressor T cells PD-L1, PD-1 ligand 1; sample size of every experimental group was 10 mice.