Figure 5.

Effects of combined treatment of anti-PD-L1 and anti-IL-6 in CRC mouse models. CT26 (A) and MC38 (B) mouse models were treated by anti-PD-L1 or anti-IL-6 at 1 week after tumor implantation. Tumor growth of these models was significantly suppressed by the combined treatment with anti-PD-L1 and anti-IL-6 antibodies. * P value less than 0.05; ** P value less than 0.01; WT – wild-type; EV – empty vector; OE – overexpression; PD-L1 – PD-1 ligand 1; sample size of every experimental group was 10 mice.