Table 1.
Serine | S3 |
S23 |
S41 |
S94 |
S156 |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) |
A | × | × | × | × | × | × | × | ||||||||
B | × | × | × | ||||||||||||
C | × | × | × | ||||||||||||
D | × | × | × | × | × | × | × | × | × | ||||||
Threonine |
T25 |
T63 |
T88 |
||||||||||||
Genotype | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | ||||||
A | × | × | × | ||||||||||||
B | |||||||||||||||
C | |||||||||||||||
D | x | × | × | × | × | × | |||||||||
Tyrosine |
Y82 |
Y85 |
Y89 |
Y140 |
|||||||||||
Genotype | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | C2-WT | C2-H222P | C2-H222P (selumetinib) | |||
A | × | × | × | × | × | × | |||||||||
B | × | × | × | × | |||||||||||
C | × | × | × | × | |||||||||||
D | × | × | × | × | × | × | × | × |