Table 2.
Echocardiographic data for Lmna+/+ (Lmna WT) transduced or not transduced with AAV-cofilin-1 and LmnaH222P/H222P (Lmna H222P) mice transduced or not transduced with AAV-cofilin-1 or AAV-cofilin-1-T25A
| Treatment | n | Age (months) | Heart rate (beats/min) | LVEDD (mm) | LVESD (mm) | FS (%) |
|---|---|---|---|---|---|---|
| Lmna WT | ||||||
| NT | 27 | 3 | 362.8±19.6 | 3.5±0.2 | 1.8±0.1 | 47.3±1.9 |
| NT | 21 | 6 | 374.8±17.6 | 3.8±0.2 | 2.1±0.2 | 45.1±2.5 |
| AAV-cofilin-1 | 5 | 6 | 338.6±41.7 | 3.8±0.3 | 2.4±0.1* | 36.8±0.9*** |
| Lmna H222P | ||||||
| NT | 16 | 3 | 306.0±43.1 | 3.9±0.3# | 2.6±0.5### | 34.4±6.6### |
| NT | 6 | 6 | 255.3±48.9 | 4.8±0.6 | 3.8±0.7 | 20.5±5.7 |
| AAV-cofilin-1 | 7 | 6 | 226.4±28.5 | 4.8±0.4 | 4.2±0.5† | 12.7±2.8†† |
| AAV-cofilin-1-T25A | 6 | 6 | 234.2±36.9 | 4.6±0.4 | 3.9±0.5 | 16.4±1.5§ |
P < 0.05 between not transduced Lmna WT mice and Lmna H222P mice (3 months of age).
P < 0.0005 between not transduced Lmna WT mice and Lmna H222P mice (3 months of age).
P < 0.005 between not transduced and AAV-cofilin-1-transduced Lmna WT mice (6 months of age).
P < 0.0005 between not transduced and AAV-cofilin-1-transduced Lmna WT mice (6 months of age).
P < 0.005 between not transduced and AAV-cofilin-1-transduced Lmna H222P mice (6 months of age).
P < 0.05 between AAV-cofilin-1-transduced and AAV-cofilin-1-T25A transduced Lmna H222P mice (6 months of age).
LVEDD, left ventricular end diastolic diameter; LVESD, left ventricular end systolic diameter; FS, fractional shortening. Data are represented as means±SEM.