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Diagrammatic representation of the many factors involved in the pathophysiology of ventricular remodeling. ECM indicates extracellular matrix; RAAS, renin-angiotensin-aldosterone system; CO, cardiac output; SVR, systemic vascular resistance; LV, left ventricular; TGF-beta 1, Transforming growth factor beta-1;ET-1, Endothelin-1 and ATII, angiotensin II.16
