Table 2.

Univariable and multivariable Cox regression analysis for sST2 as predictor of 1-year cardiac mortality and need for re-hospitalization in patients with heart failure.

Variables	Univariable		Multivariable
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age (years)	1.032 (0.997–1.067)	0.070	1.028 (0.978–1.081)	0.283
Male gender	0.646 (0.323–1.292)	0.217
Body mass index	0.920 (0.840–1.010)	0.076	0.937 (0.847–1.038)	0.212
Hypertension	0.613 (0.300–1.252)	0.179
Diabetes	0.467 (0.194–1.122)	0.089	0.818 (0.318–2.100)	0.676
Dyslipidemia	0.349 (0.169−0.725)	0.005	0.905 (0.402–2.038)	0.810
History of CAD	0.742 (0.379–1.453)	0.384
History of CVD	0.784 (0.277–2.220)	0.646
Ischemic aetiology of HF	0.501 (0.065–3.837)	0.505
Current smoking	0.549 (0.280–1.077)	0.081	0.596 (0.224–1.583)	0.299
Alcoholism	0.540 (0.274–1.065)	0.075	0.616 (0.214–1.776)	0.370
NYHA functional class	3.336 (1.828–6.08)	0.000	1.512 (0.717–3.189)	0.004
ACE-I/ARB	0.335 (0.170–0.661)	0.002	0.335 (.155−0.723)	0.005
β-blockers	0.180 (0.092–0.351)	0.000	0.325 (0.156–0.680)	0.003
MRA	1.228 (0.538–2.806)	0.626
Creatinine clearance	0.993 (0.980–1.007)	0.338
sST2, ng/ml	2.810 (1.997–3.996)	0.000	2.046 (1.246–3.358)	0.005

Variables were included in multivariable analysis (p < 0.1); The logarithm function of sST2 was used in the analysis. ACE-I – angiotensin converting enzyme inhibitor; ARB – Angiotensinogen receptor blocker; CAD- coronary artery disease; CVD- cerebrovascular disease CI – confidence interval; HR- hazard ratio; NYHA – New York Heart Association.