Table 2.

The performance of circulating miR-222-3p and miR-221/.222 Ct ratio for predicting isolated low HDL-C phenotype

Models	AUC (95%CI)	p value	Cut-off value	Specificity	Sensitivity
miR-222-3p	0.648 (0.566, 0.730)	< 0.001	0.559	0.837	0.432
The miR-221-3p/miR-222-3p ratio	0.678 (0.598, 0.758)	< 0.001	0.562	0.767	0.568
Clinical model	0.771 (0.702, 0.840)	< 0.001	0.462	0.698	0.761
Clinical model + miR-222-3pa	0.816 (0.754, 0.879) b	< 0.001	0.413	0.663	0.879
Clinical model + miR221-3p/miR-222-3p ratioa	0.813 (0.751, 0.876) b	< 0.001	0.423	0.686	0.818

AUC area under the curve. Best threshold of Cut-off value were estimated using youden method. ^a The AUC, sensitivities and specificities of the combination model of miR-222-3p and clinical model was compared with that of clinical model. ^bp < 0.05