Table 3.
The AUCs’ performance for distinguishing subjects with isolated low HDL-C phenotype in gender-based analysis
| Models | AUC (95%CI) | p value | Cut-off value | Specificity | Sensitivity |
|---|---|---|---|---|---|
| Male subjects | |||||
| miR-222-3p | 0.671 (0.566, 0.730) | 0.002 | 0.474 | 0.667 | 0.622 |
| miR-221-3p/miR-222-3p ratio | 0.731 (0.626, 0.836) | < 0.001 | 0.564 | 0.800 | 0.622 |
| Clinical model | 0.759 (0.659, 0.859) | < 0.001 | 0.630 | 0.867 | 0.556 |
| Clinical model + miR-222-3pa | 0.813 (0.721, 0.904) | < 0.001 | 0.522 | 0.800 | 0.778 |
| Clinical model + miR-221-3p/miR-222-3p ratioa | 0.851 (0.770, 0.933)c | < 0.001 | 0.430 | 0.756 | 0.889 |
| Female subjects | |||||
| miR-222-3p | 0.623 (0.501, 0.745) | 0.026 | 0.600 | 0.878 | 0.417 |
| miR-221-3p/miR-222-3p ratio | 0.624 (0.503, 0.745) | 0.025 | 0.566 | 0.780 | 0.512 |
| Clinical model | 0.808 (0.714, 0.901) | < 0.001 | 0.548 | 0.854 | 0.674 |
| Clinical model + miR-222-3pb | 0.847 (0.761, 0.934) | < 0.001 | 0.421 | 0.780 | 0.837 |
| Clinical model + miR-221-3p/miR-222-3p ratiob | 0.841 (0.756, 0.926) | < 0.001 | 0.556 | 0.853 | 0.721 |
AUC area under the curve. Best threshold of Cut-off value were estimated using youden method
a, b The AUC, sensitivities and specificities of the combination model of either miR-222-3p or miR-221-3p/miR-222-3p ratio and clinical indexes were compared with that of the predictive clinical model for male and female subjects, respectively
cp < 0.05