Table 3.
Agreement of retinal layer thickness measures derived from Heidelberg segmentation of horizontally and vertically acquired Spectralis OCT macular scans.
| Average thickness(SD)(µm) | Mean difference(95% CI)(µm) | Lower LOA (95% CI)(µm)) | Upper LOA (95% CI) (µm) | |||||
|---|---|---|---|---|---|---|---|---|
| HC cohort | MS patient cohort | HC cohort | MS patient cohort | HC cohort | MS patient cohort | HC cohort | MS patient cohort | |
| mRNFL | 26.6 (2.56) | 24.64(4.25) | 0.98 (0.61 to 1.35) | 0.96 (0.59 to 1.33) | −1.35 (−1.99 to −0.71) | −1.38 (−2.02 to −0.74) | 3.32 (2.68 to 3.96) | 3.3 (2.66 to 3.95) |
| GCIP | 75.94 (3.8) | 64.34 (11.29) | 0.18(−0.05 to 0.4) | −0.08 (−0.24 to 0.4) | −1.26 (−1.65 to −0.86) | −1.93 (−2.48 to −1.38) | 1.61(1.22 to 2) | 2.09 (1.54 to 2.64) |
| INL | 35.28 (2.3) | 34.38 (3.39) | 0.03 (−0.24 to 0.3) | −0.19 (−0.42 to 0.05) | −1.7 (−2.18 to −1.23) | −1.69 (−2.1 to −1.28) | 2.62 (2.14 to 3.09) | 2.27 (1.86 to 2.69) |
| OPL | 29.01 (2.67) | 28.15 (2.32) | −0.3 (−0.89 to 0.3) | −0.3 (−0.92 to 0.3) | −4.05 (−5.08 to −3.02) | −4.15 (−5.2 to −3.1) | 3.46 (2.43 to 4.49) | 3.53 (2.48 to 4.58) |
| ONL | 70.41 (8.63) | 65.91 (6.76) | 0.12 (−0.45 to 0.7) | 0.25 (−0.32 to 0.83) | −3.51 (−4.5 to −2.5) | −3.37 (−4.36 to −2.38) | 3.75 (2.76 to 4.75) | 3.88 (2.88 to 4.87) |
| RPE | 14.59 (0.92) | 14.06 (1.4) | −0.38 (−0.55 to −0.21) | −0.32 (−0.49 to −0.14) | −1.45 (−1.74 to −1.15) | −1.41 (−1.71 to −1.11) | 0.68 (0.39 to 0.97) | 0.78 (0.48 to 1.08) |
SD =standard deviation; CI =confidence interval); LOA=limit of agreement
mRNFL =macular retinal nerve fiber layer; GCIP=ganglion cell inner plexiform layer; INL=inner nuclear layer; OPL=outer plexiform layer; ONL=outer nuclear layer; RPE=retinal pigment epithelium