Table 1. Brain disorder phenotypes used in the Brainstorm project.
Indented phenotypes are part of a larger whole (e.g., the epilepsy study contains the samples from both focal epilepsy and generalized epilepsy). “Anxiety disorders” refers to a meta-analysis of five subtypes (generalized anxiety disorder, panic disorder, social phobia, agoraphobia, and specific phobias). References are listed in table S1 and data availability in table S13 PGC-ADD2, Psychiatric Genomics Consortium (PGC) Attention Deficit Disorder Working Group; PGC-ED, PGC Eating Disorder Working Group; ANGST, Anxiety Neuro Genetics STudy; PGC-AUT, PGC Autism Spectrum Disorder Working Group; PGC-BIP2, PGC Bipolar Disorder Working Group; PGC-MDD2, PGC Major Depressive Disorder Working Group; PGC-OCDTS, PGC Obsessive Compulsive Disorder and Tourette Syndrome Working Group; PGC-PTSD, PGC Posttraumatic Stress Disorder Working Group; PGC-SCZ2, PGC Schizophrenia Working Group; IGAP, International Genomics of Alzheimer’s Project; ILAE, International League Against Epilepsy Consortium on Complex Epilepsies; ISGC, International Stroke Genetics Consortium; METASTROKE, a consortium of the ISGC; IHGC, International; Headache Genetics Consortium; IMSGC, International Multiple Sclerosis Genetics Consortium; IPDGC, International Parkinson’s Disease Genomics Consortium. W indicates same as above.
| Psychiatric disorders | Neurological disorders | ||||||
|---|---|---|---|---|---|---|---|
| Disorder | Source | Cases | Controls | Disorder | Source | Cases | Controls |
| Attention deficit hyperactivity disorder | PGC-ADD2 | 12,645 | 84,435 | Alzheimer’s disease | IGAP | 17,008 | 37,154 |
| Anorexia nervosa | PGC-ED | 3495 | 10,982 | Epilepsy | ILAE | 7779 | 20,439 |
| Anxiety disorders | ANGST | 5761 | 11,765 | Focal epilepsy | “ | 4601* | 17,985* |
| Autism spectrum disorder | PGC-AUT | 6197 | 7377 | Generalized epilepsy | “ | 2525* | 16,244* |
| Bipolar disorder | PGC-BIP2 | 20,352 | 31,358 | Intracerebral hemorrhage | ISGC | 1545 | 1481 |
| Major depressive disorder | PGC-MDD2 | 66,358 | 153,234 | Ischemic stroke | METASTROKE | 10,307 | 19,326 |
| Obsessive-compulsive disorder | PGC-OCDTS | 2936 | 7279 | Cardioembolic stroke | “ | 1859* | 17,708* |
| Posttraumatic stress disorder | PGC-PTSD | 2424 | 7113 | Early onset stroke | “ | 3274* | 11,012* |
| Schizophrenia | PGC-SCZ2 | 33,640 | 43,456 | Large-vessel disease | “ | 1817* | 17,708* |
| Tourette syndrome | PGC-OCDTS | 4220 | 8994 | Small-vessel disease | “ | 1349* | 17,708* |
| Migraine | IHGC | 59,673 | 316,078 | ||||
| Migraine with aura | “ | 6332* | 142,817* | ||||
| Migraine without aura | “ | 8348* | 136,758* | ||||
| Multiple sclerosis | IMSGC | 5545 | 12,153 | ||||
| Parkinson’s disease | IPDGC | 5333 | 12,019 | ||||
| Total psychiatric | 158,028 | 365,993 | Total neurologic | 107,190 | 418,650 | ||
Sample count for a phenotype that is part of a larger group.