TABLE 3.
Summary of Reviewed Genes
| Gene Symbol* | No. of Studies | Country | No. of Variants |
|---|---|---|---|
| APC | 4 | Canada, Germany, Israel, US | 3 |
| ATM | 9 | Canada, Germany, Japan, US | 22 |
| BARD1 | 1 | US | 1 |
| BRCA1 | 19 | Canada, Israel, Italy, Poland, Sweden, US | 26 |
| BRCA2 | 31 | Canada, Germany, Iceland, Israel, Italy, Japan, Korea, Spain, UK, US | 87 |
| CDKN2A | 16 | Canada, Germany, Italy, Netherlands, Poland, US | 46 |
| CFTR | 10 | Belgium, Germany, Italian, Spain, UK, US | 15 |
| CHEK2 | 5 | Czech Republic, Germany, Poland, US | 4 |
| FANCA | 2 | US | 13 |
| FANCC | 3 | US | 13 |
| FANCM | 1 | US | 1 |
| MLH1 | 6 | Canada, Italy, Japan, US | 8 |
| MSH2 | 6 | Canada, Ireland, Italy, US | 12 |
| MSH6 | 3 | Canada, US | 8 |
| NBN | 2 | Czech Republic, US | 1 |
| PALB2 | 14 | Canada, Czech Republic, Germany, Italy, Japan, Poland, Spain, US | 52 |
| PALLD | 3 | Canada, US | 3 |
| PMS2 | 2 | US | 7 |
| PRSS1 | 4 | France, Spain, UK | 4 |
| SPINK1 | 5 | Finland, Germany, Italy, Japan, US | 3 |
| STK11 | 2 | Italy, US | 2 |
| TP53 | 6 | Canada, Czech Republic, Japan, US | 6 |
*
Gene symbols follow the Hugo Gene Nomenclature Committee [HGNC] Gene ID.
US indicates, United States; UK, United Kingdom.