Table 2.
Hepatic function, fasting blood glucose and insulin concentrations in mice 1,2,3,4
| ALT (U/L) | AST (U/L) | Glucose (mg/dL) | Insulin (µg/L) | HOMA-IR index | |
|---|---|---|---|---|---|
| Con (4) | 16 ± 6 | 36 ± 13 | 155 ± 49 | 0.2 ± 0.1 | 2.2 ± 1.0 |
| HFD (4) | 36 ± 18 # | 37 ± 6 | 213 ± 48 # | 0.5 ± 0.1 # | 6.8 ± 3.0 # |
| Con (8)+saline | 16 ± 5 a | 42 ± 15 a | 136 ± 27 ab | 0.3 ± 0.1 a | 2.1 ± 0.8 a |
| HFD (8)+saline | 45 ± 17 c | 69 ± 14 c | 228 ± 73 c | 0.8 ± 0.3 c | 11.0 ± 5.9 c |
| HFD (8)+LBNG | 31 ± 7 b | 51 ± 7 b | 178 ± 41 b | 0.6 ± 0.1 b | 6.2 ± 1.5 b |
| HFD (8)+MBNG | 23 ± 8 ab | 46 ± 6 ab | 135 ± 41 ab | 0.3 ± 0.1 a | 2.2 ± 1.0 a |
| HFD (8)+HBNG | 18 ± 4 a | 40 ± 9 a | 130 ± 32 a | 0.3 ± 0.1 a | 2.7 ± 2.3 a |
1 Values are means ± SD.
2 Con (4) = mice received standard control diet for 4 weeks (n=7); HFD (4) = mice received high fat diet for 4 weeks (n=7); Con (8)+saline = mice received standard control diet for 8 weeks (n=7); HFD (8)+saline (n=10), HFD (8)+LBNG (n=10), HFD (8)+MBNG (n=10), and HFD (8)+HBNG (n=10) groups = mice received high fat diet for 8 weeks and supplemented daily with 0, 0.026, 0.035, and 0.052 g BNG-1/30 g body weight at the last 4 weeks, respectively.
3 ALT = Alanine Aminotransferase; AST = Alanine Aminotransferase; HOMA-IR = fasting insulin (pmol/L) x fasting glucose (mmol/L)/22.5.
4 #p < 0.05 vs Con (4) group; additionally, values in the same column with different superscripts are significantly different (p < 0.05).