Table 5.
SNP | Chr | Position (Mb) | BF | MAF | SNP effect | Windowsb | % Varc | Candidate Genesd |
---|---|---|---|---|---|---|---|---|
rs133244984 | 3 | 45.30 | 61.24 | 0.32 | 0.00221 | Chr3_46 | 8.67 | DPYD |
rs137051934 | 16 | 20.84 | 57.29 | 0.40 | 0.00190 | Chr16_21 | 5.13 | – |
rs135408640 | 3 | 45.29 | 35.74 | 0.41 | 0.00117 | Chr3_46 | 8.67 | DPYD |
rs42014753 | 22 | 51.60 | 33.97 | 0.37 | 0.00112 | Chr22_52 | 1.73 | UBA7, IP6K1, GMPPB, RNF123, MST1, APEH, AMT, RHOA, USP4, USP19, IMPDH2, NDUFAF3, SLC25A20, PRKAR2A, IP6K2, UQCRC1, UCN2, PFKFB4, SHISA5 |
rs110480161 | 5 | 22.01 | 33.44 | 0.45 | 0.00110 | Chr5_23 | 2.38 | BTG1 |
rs136349671 | 3 | 44.37 | 32.98 | 0.39 | 0.00106 | Chr3_45 | 1.65 | PLPPR4, PLPPR5 |
rs137143404 | 3 | 41.54 | 27.60 | 0.50 | −0.00087 | Chr3_42 | 1.54 | – |
rs135488380 | 3 | 45.34 | 23.95 | 0.34 | 0.00079 | Chr3_46 | 8.67 | DPYD |
rs137135953 | 28 | 41.34 | 23.88 | 0.37 | 0.00074 | Chr28_42 | 0.84 | BMPR1A, ADIRF, GLUD1 |
rs133451489 | 12 | 4.46 | 23.48 | 0.39 | −0.00072 | Chr12_5 | 1.69 | – |
rs109757968 | 21 | 62.41 | 20.46 | 0.33 | 0.00065 | Chr21_63 | 0.67 | TCL1B, TCL1A, BDKRB2, BDKRB1, AK7 |
rs136908466 | 5 | 22.06 | 20.28 | 0.43 | −0.00063 | Chr5_23 | 2.38 | BTG1 |
rs137014141 | 14 | 14.47 | 20.16 | 0.35 | 0.00062 | Chr14_15 | 0.85 | – |
a Single nucleotide polymorphisms (SNPs) that showed a strong association with ln_ according Bayes Factor (BF > 20)
b Represented by chromosome (Chr) and physical position (in Mb) (i.e. Chr_Mb)
c Proportion of genetic variance in each 1-Mb window
d Ensembl Database UMD3.1. See the complete gene list in each window in Additional file 1